The Department of Cell Biology and Human Anatomy at the University of California, Davis, School of Medicine, seeks to hire a full-time employee as a Junior Specialist to perform research functions in the laboratory of Nadean Brown, investigating the roles of transcription factors during embryonic retinal development.
The Junior Specialist hired for this position will participate in interdisciplinary studies that focus on questions in embryonic development, tissue growth and formation, and human structural birth defects. The candidate must have a degree in Genetics, Biochemistry or a related field with a minimum of one year of research experience in a laboratory. The Junior Specialist will collaboratively and creatively conduct experiments using genetics, mouse models, immunohistochemistry, molecular biology and protein biochemistry. Other general responsibilities include reviewing journal articles and engaging in discussion of research and the interpretation of research results; participating and presenting in vision group, departmental (Research in Progress talks) and/or campus-wide seminars, as well as at national and international research conferences; reviewing research proposals, journal manuscripts and publications related to bHLH transcription factor regulation of neurogenesis.
MAJOR RESPONSIBILITIES AND DESIGNATED AREAS OF EXPERTISE:
1. **RESEARCH (80% EFFORT) The Junior Specialist is expected to work closely with the Principle Investigator (PI) to carry out experiments to investigate the role of Hes1, Hes3 and Hes5 bHLH transcription factors during embryonic stages of retinal development including RGC and cone neuron formation. The specific roles and duties include generation of conditional, single, double and/or triple mutant embryos, analysis of mouse mutant anatomical and histologic defects and testing an extensive panel of developmental markers among the various genotypes of tissues generated. All findings will be presented in national and international conferences and published as peer-reviewed research article(s) in internationally recognized scientific journals.
The Junior Specialist is expected to study the current literature and attend scientific conferences, think critically and creatively, and meet with the PI on a regular basis (at least once per week) to formulate research hypothesis and design experiments. The Junior Specialist will be responsible for executing experiments, collecting and interpreting the results first independently, and then discuss the results and conclusions with the PI. The Junior Specialist will formulate future hypotheses based on the obtained data, and design/revise future experimental plans in consultation with the PI.
The Junior Specialist is expected to gain a strong knowledge base about bHLH transcription factors, retinal development, neurogenesis, and retinal cell fate changes through independent study and literature reading. Through these exercises, the Junior Specialist will identify knowledge gaps in the field, generate new hypotheses and collaboratively design the most informative and creative experiments to test hypotheses. The Junior Specialist will study and understand the rationales behind experimental procedures, creatively tailor protocols to our specific experimental conditions. The Junior Specialist will also independently and creatively troubleshoot any technical hurdles that may be encountered during the experiments. In many cases, the Junior Specialist will also be expected to design and carry out completely new experimental procedures.
2. **PROFESSIONAL COMPETENCE AND ACTIVITY (10% EFFORT) The Junior Specialist will give oral or poster presentations at regional, national or international conferences, such as the West Coast Developmental Biology Meeting, Visual Systems Development GRC Meeting. They will also participate in all other associated activities of these conferences, such as career workshops.
The Junior Specialist will be a member of the Society for Developmental Biology.
3. **UNIVERSITY AND PUBLIC SERVICE (10% EFFORT) The Brown lab has multiple undergraduate researchers, and expects to recruit more in the coming year. We also periodically mentor Davis High School Biotechnology intern students. The Junior Specialist is expected to take on the mentorship of these students. The Junior Specialist will also share expertise in mouse breeding and genetics, immunohistochemistry, histology, and molecular techniques with other research groups in the department and/or university. BASIC QUALIFICATIONS:
Bachelor degree in biology or a related field (must receive degree by June 30, 2019 or before start date).
1 year of research laboratory experience is required.
Experience working with genetically modified mice that may include breeding mutant mouse lines and PCR genotyping.
Experience in histology, preparation tissues for antibody labeling and/or microscope wild field confocal imaging
Experience in molecular biology assays such as (but not limited to) restriction-enzyme based ligation, subcloning, quantification of nucleic acids
The ideal candidate will have strong interpersonal, communication, and decision-making skills; as well as the ability to work well independently and as part of a team.
Display strong organizational skills that are needed to maintain databases of inventories and details of multiple simultaneous experiments
TERM OF APPOINTMENT: Full time 100%, 12 months (initial). Expected start date is July 1, 2019.
TO APPLY: To apply, please go to the following link: https://recruit.ucdavis.edu/JPF02809 For full considerations applications must be received by May 15, 2019; however, the position will remain open until filled through December 31, 2019.
Qualified applicants should submit:
Cover letter detailing your qualifications for this position
Contact information for 3 references
UC Davis commits to inclusion excellence by advancing equity, diversity and inclusion in all that we do. We are an Affirmative Action/Equal Opportunity employer, and particularly encourage applications from members of historically underrepresented racial/ethnic groups, women, individuals with disabilities, veterans, LGBTQ community members, and others who demonstrate the ability to help us achieve our vision of a diverse and inclusive community. For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct. If you need accommodation due to a disability, please contact the recruiting department.
Under Federal law, the University of California may employ only individuals who are legally able to work in the United States as established by providing documents as specified in the Immigration Reform and Control Act of 1986. Certain positions funded by federal contracts or sub-contracts require the selected candidate to pass an E-Verify check. More information is available http://www.uscis.gov/e-verify.
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