Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
This position is full-time and works approximately 40 hours per week.
Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Division of Infectious Diseases. This position is for the Medical School Campus.
A postdoctoral position is available in the laboratory of Dr. Liang Shan in the Division of Infectious Diseases at Washington University School of Medicine. The newly established lab mainly focuses on HIV infection and virus-specific human T cell and NK cell responses in novel humanized mouse models. This position will provide an excellent opportunity for the successful candidate to pursue a career in the field of virology or immunology.
Characterization of HIV-1 latent reservoir in tissue-resident CD4+ T cells and tissue macrophages
Development of CTL-based strategies to eliminate circulating and tissue residing latent reservoirs for HIV-1
Development of antibody-based immunological approaches to control HIV-1 infection and eliminate latent HIV-1
Generation of patient-derived humanized mouse models as a preclinical platform to evaluate vaccine efficacy
Publications related to the projects associated with the position:
Shan L*, Deng K*, Gao H, Xing S, Capoferri AA, Durand CM, Rabi SA, Laird GM, Kim M, Hosmane NN, Yang HC, Zhang H, Margolick JB, Li L, Cai W, Ke R, Flavell RA, Siliciano JD, Siliciano RF. Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 Infection. Immunity. 2017 Oct 17;47(4):766-775. * Co-first author.
Herndler-Brandstetter D*, Shan L*, Yao Y, Stecher C, Plajer V, Lietzenmayer M, Strowig T, de Zoete MR, Palm NW, Chen J, Blish CA, Frleta D, Gurer C, Macdonald LE, Murphy AJ, Yancopoulos GD, Montgomery RR, Flavell RA. Humanized mouse model supports development, function, and tissue residency of human natural killer cells. Proc Natl Acad Sci USA. 2017 Nov 7;114(45). * Co-first author.
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Bhiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks SG, Strowig T, Kumar P, Siliciano JD, Salzberg SL, Flavell RA*, Shan L*, Siliciano RF*. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature. 2015 Jan 15;517(7534):381-5. * Co-corresponding author.
Shan L, Deng K, Shroff NS, Durand CM, Rabi SA, Yang HC, Zhang H, Margolick JB, Blankson JN, Siliciano RF. Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity. 2012 Mar. 36(3): 491-501
A PhD degree in microbiology, immunology or a similar field.
Willingness to conduct research using mouse models.
Strong written and oral communication skills are essential, as evidenced by high-quality international peer-reviewed journals.
Ability to work independently and communicate with laboratory staff and investigators.
The hiring range for this position is commensurate with experience.
This position is eligible for full-time benefits.� Please visit our website at http://hr.wustl.edu to view a summary of benefits.
Applicant Special Instructions:
To apply, please e-mail a cover letter, CV, and the names and contact information for three references to Dr. Liang Shan at firstname.lastname@example.org.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
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